you must start regedit ( start -> run [See screenshots at the bottom] Type here: regedit )
search the HKEY_LOCAL_MACHINE/SYSTEM/CurrentControlSet/Control/Class/ search for "4D36E965-E325-11CE-BFC1-08002BE10318" if you doesn't find anything, search only for a part of the string.
now search the propertys UpperFilter an LowersFilter and kill the value. If only one prop. is there, you must kill only the one value
Hey DeadMatt, you are a genious. I arrived here seeking desperatly for a solution or a driver, because suddenly my drive stopped working. The laptop is a fujitsu N6460 about two weeks old, vista home premium. Am pretty sure windowsupdate ruined the driver settings, but now is working again. As an additional problem, I could not read the drivers cd, because well, no cd! Your recommendation on tweaking the registry worked perfectly.
DeadMatts solution worked a treat. Got my DVD drive back and working. I used CD's to install various software options on day of new notebook delivery then DVD drive dissapeared. I reckon it must have occured during a microsoft auto update...anyway, thanks to DeadMatt, all fixed.
and now my disc drive does not work 
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start-run-program.jpg
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